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The channel's most popular original shows are The Shield, Nip/Tuck, Damages, Rescue Me, Sons of Anarchy, Justified and American Horror Story, as well as the comedies It's Always Sunny in Philadelphia, Louie, The League, Wilfred and Anger Management. Aside from new episodes of its ongoing series, the channel mainly airs re-runs originally broadcast on Fox in the 1990s and 2000s.

In 2010, Sons of Anarchy attracted an average of 4.9 million viewers per week, making it FX's highest rated series to date, surpassing other hits The Shield, Nip/Tuck, Rescue Me and Damages.[1]